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RiDYMO® Platform Drives New Breakthroughs in highly potent PLK1 Inhibitors Development [Yahoo! Finance]

Cardiff Oncology, Inc. (CRDF) 
Company Research Source: Yahoo! Finance
PLK1 is a protein kinase that plays a crucial role in cellular mitosis and is overexpressed in various cancers. The platform was used to analyze the interactions between PLK1 and a known inhibitor, PCM-075, and to design and test new compounds. The study resulted in the identification of several preclinical candidate compounds with improved activity and pharmacokinetic properties, including DP226, which showed a 300-fold improvement in activity compared to the original compound. The RiDYMO platform's ability to accelerate the drug development process and provide high-efficiency support in early-stage drug discovery holds promise for the development of new cancer treatments. BEIJING Nov. 19, 2024 /PRNewswire/ -- With the support of the RiDYMO® platform, we are able to comprehensively explore various potential targets in drug development, including protein-protein interactions, kinases, GPCRs, ion channels, and transcription factors. Polo-like kinase 1 (PLK1) is a highly conserved s Show less Read more
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