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Stock impact report

Cardiff Oncology announces positive colorectal data and $40m stock oversubscription [Yahoo! Finance]

Cardiff Oncology, Inc. (CRDF) 
Company Research Source: Yahoo! Finance
evaluating onvansertib in combination with standard-of-care (SoC) in patients with first-line RAS-mutated metastatic colorectal cancer (mCRC). The Phase II trial (NCT06106308) has a primary endpoint of objective response rate (ORR) and secondary endpoints including progression-free survival (PFS), duration of response (DOR) and safety. There were 30 evaluable patients at the cut-off point (26 November), randomised in a 1:1:1 ratio. A third received 20mg of onvansertib alongside SoC, a third received 30mg alongside SoC and a third received only SoC. The 30mg dose arm demonstrated 64% ORR, compared to 50% in the 20mg arm, and 33% ORR in the control arm. Deeper tumour regression was also noted in the 30mg arm of the study. Fairooz Kabbinavar, chief medical officer of Cardiff Oncology, said of the results: “Our data shows an objective response rate of 64% in patients receiving the 30mg dose of onvansertib in combination with standard of care, significantly higher than the 33% obje Show less Read more
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