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0.0288421920065925 0.0288421920065925 0.0288421920065925 0.0288421920065925 0.0241038318912238 -0.00412031314379884 -0.0163782447466006 -0.0212196126905644
Stock impact report

Corcept's relacorilant GRADIENT trial misses primary endpoint [Yahoo! Finance]

Corcept Therapeutics Incorporated (CORT) 
Last corcept therapeutics incorporated earnings: 2/20 04:05 pm Check Earnings Report
US:NASDAQ Investor Relations: corcept.com/investors
Company Research Source: Yahoo! Finance
The trial will be used alongside data from the earlier GRACE trial to support the company's new drug application (NDA) submission this quarter. However, it missed its primary endpoint. The complete results of the company's GRADIENT trial will be presented at a medical conference next year, but current results – released on 30 October – demonstrate that there was no statistically significant difference in hypertension in relacorilant and placebo patients. The randomised double-blind trial included 137 patients across sites in the US, Europe and Israel. Over 22 weeks, half of the patients received relacorilant while the other half received a placebo. The trial's primary endpoint was the improvement in systolic blood pressure (SBP) compared to placebo. Its secondary endpoints were concerned with hyperglycemia, weight and body composition. Mean SBP saw a reduction of 6.6 mm Hg in relacorilant patients compared to baseline. This is in contrast to a reduction of 2.1 mm Hg in placeb Show less Read more
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