Celgene Updated Analysis of JAKARTA2 Fedratinib Study Shows Clinically Meaningful Responses in Patients Previously Treated for Myelofibrosis with Ruxolitinib
CELGENE (CELG)
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Source: Business Wire
SUMMIT, N.J.--(BUSINESS WIRE)-- Celgene Corporation (NASDAQ: CELG) announced an updated analysis of data from the Phase 2 JAKARTA2 clinical study demonstrating clinically meaningful response rates with investigational fedratinib in patients with myelofibrosis previously treated with ruxolitinib. This updated analysis of fedratinib employed intent-to-treat (ITT) principles and utilized a narrower definition of ruxolitinib relapsed, refractory, or intolerant patients. Results were shared in a poster presentation today at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. In the ITT population (n=97), the proportion of patients who exhibited a 35% or greater reduction in spleen volume at end of cycle 6 was 31% (95% CI 22, 41). Of these 97 patients, 79 (81%) met the narrower criteria for ruxolitinib resistance or intolerance. In this cohort, the proportion of patients who exhibi
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