CymaBay Therapeutics Reports Topline 12-Week Data from an Ongoing Phase 2b Study of Seladelpar in Patients with Nonalcoholic Steatohepatitis
CymaBay Therapeutics Inc. (CBAY)
Last cymabay therapeutics inc. earnings: 3/12 04:01 pm
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Source: GlobeNewswire
- Reductions in liver fat were minimal and not significant compared to placebo- Reductions in markers of liver injury were robust and clinically meaningful- Seladelpar appears to be safe and well-tolerated across all doses - Blinded study will continue to 52-week liver biopsy- Conference call today at 8 a.m. ET NEWARK, Calif., June 11, 2019 (GLOBE NEWSWIRE) -- CymaBay Therapeutics, Inc. (NASDAQ: CBAY) today announced 12-week topline results from an ongoing 52-week Phase 2b dose-ranging, paired liver biopsy study of seladelpar for the treatment of nonalcoholic steatohepatitis (NASH). Seladelpar is a potent and selective peroxisome proliferator-activated receptor delta (PPARd) agonist currently in development for NASH and primary biliary cholangitis (PBC). The double-blind, placebo-controlled study randomized 181 subjects with biopsy-confirmed NASH and a liver fat content (LFC) greater than 10% to receive either placebo or seladelpar 10 mg, 20 mg, or 50 mg once-daily. The e
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