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Duality Biologics and BioNTech Presented Positive Interim Data for Investigational B7-H3 Antibody-Drug Conjugate BNT324/DB-1311 in Advanced Solid Tumors at the ESMO Asia Congress 2024 [Yah...

BioNTech SE - American Depositary Shares (BNTX) 
Company Research Source: Yahoo! Finance
with locally advanced or metastatic solid tumors, including small cell lung cancer ("SCLC"), non-small cell lung cancer ("NSCLC"), and castration-resistant prostate cancer ("CRPC"). In patients with SCLC with at least one post-baseline tumor assessment and who had received prior immunotherapy but no prior topoisomerase 1 inhibitor, the unconfirmed objective response rate ("uORR") was 70.4% at the BNT324/DB-1311 9 mg/kg dose level. In patients with CRPC, the uORR was 28.0%; imaging progression-free survival ("rPFS") data are not yet mature, with a median rPFS of 7.2 months and a 6-month rPFS rate of 94.7%. Multiple clinical trials combining selected assets from BioNTech's and DualityBio's strategic partnership with BNT327/PM8002, an investigational bispecific antibody targeting PD-L1 and VEGF-A, are planned; a Phase 1/2 trial evaluating BNT324/DB-1311 with BNT327/PM8002 in patients with SCLC or NSCLC is planned to start in 2025. SHANGHAI and SUZHOU, China Dec. 5, 2024 /PRNewswi Show less Read more
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