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0.000489510489510436 0.000489510489510436 0 0.0489160839160839 0.0314335664335663 0.0142307692307691 -0.0244755244755246 -0.06993006993007
Stock impact report

Icovamenib Treatment in Patients with Severe Insulin-Deficient Diabetes Led to a Significant Improvement in Pancreatic Beta-cell Function with a 53% Mean Increase in C-peptide Levels 3 Mon...

Biomea Fusion, Inc. (BMEA) 
Company Research Source: Yahoo! Finance
Strong correlation between C-peptide increase and HbA1c reduction (r = -0.73, p Best response observed in prespecified, beta-cell deficient patients on one or more antihyperglycemic agents at baseline, achieving a statistically significant placebo-adjusted mean reduction in HbA1c of 1.47% at Week 26 (p=0.022), after only 12 weeks of 100 mg once daily icovamenib Preclinical in vivo experiments indicated that icovamenib enhanced the responsiveness of human islets to GLP-1-based medicines, consistent with the increase in expression levels (transcript and protein) of both the GLP-1 receptor and intracellular insulin Severe Insulin Deficient Diabetes represents an underserved patient population within type 2 diabetes and is estimated to be over 100 million pe Read more
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