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Stock impact report

DSMB recommends continuation of BioCardia's cell therapy trial for heart failure [Yahoo! Finance]

BioCardia, Inc. (BCDA) 
Company Research Source: Yahoo! Finance
The decision comes after an assessment of 30-day safety data from subjects who were treated in the trial's low-dose 20 million cell cohort. This data did not show any treatment-emergent adverse cardiac events or immune reactions to the implanted allogeneic cells. Following the DSMB's approval, BioCardia aims to advance the study by enrolling 39 subjects across the US. The trial aims to explore the efficacy and safety of mesenchymal stromal/stem cells (MSCs) in treating heart failure. It involves a nine-patient, open-label Phase I dose escalation cohort, followed by a randomised placebo procedure-controlled double-blinded 30-patient cohort. In Phase I of the trial, three subjects will receive treatments at dosages of either 20 million, 100 million and 200 million cells. These treatments will be administered using the Helix delivery system, which is designed to be minimally invasive. BioCardia said that at high dosage levels, the CardiALLO-HF trial will provide at least t Show less Read more
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