AstraZeneca Imfinzi regimen for endometrial cancer gains FDA approval [Yahoo! Finance]
AstraZeneca PLC - American Depositary Shares (AZN)
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Source: Yahoo! Finance
treating adults with primary advanced or recurrent endometrial cancer that is mismatch repair deficient (dMMR). The treatment regimen comprises Imfinzi plus chemotherapy including carboplatin and paclitaxel, followed by Imfinzi monotherapy. This approval from the FDA is based on a subgroup analysis from the DUO-E Phase III trial, which focused on MMR status. The randomised, multicentre, double-blind, placebo-controlled study assessed Imfinzi plus platinum-based chemotherapy followed by either Imfinzi monotherapy or Imfinzi plus Lynparza (olaparib), against chemotherapy alone. It included 699 patients with newly diagnosed advanced or recurrent epithelial endometrial carcinoma. Patients in the trial were randomised to receive Imfinzi or a placebo every three weeks, alongside platinum-based chemotherapy. Results showed that the Imfinzi combination regimen reduced the risk of disease progression or death by 58% in patients versus chemotherapy alone. Imfinzi and chemotherapy
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Sec Filings
- 6/25/24 - Form 6-K
- 6/25/24 - Form 6-K
- 6/18/24 - Form 6-K
- AZN's page on the SEC website