IMFINZI® (durvalumab) plus chemotherapy approved in the US for mismatch repair deficient advanced or recurrent endometrial cancer [Yahoo! Finance]
AstraZeneca PLC - American Depositary Shares (AZN)
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Source: Yahoo! Finance
WILMINGTON, Del., June 17, 2024 BUSINESS WIRE )--AstraZeneca's IMFINZI ® (durvalumab) in combination with carboplatin and paclitaxel followed by IMFINZI monotherapy has been approved in the US as treatment for adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair deficient (dMMR). The approval by the Food and Drug Administration (FDA) was based on the results of a prespecified exploratory subgroup analysis by MMR status in the DUO-E Phase III trial. Results from DUO-E were published in the Journal of Clinical Oncology In the trial, IMFINZI plus carboplatin and paclitaxel followed by IMFINZI monotherapy (IMFINZI arm) reduced the risk of disease progression or death by 58% in patients with dMMR endometrial cancer versus chemotherapy alone (hazard ratio 0.42; 95% confidence interval 0.22-0.80). In the US, endometrial cancer is the fourth most common cancer in women, with more than 66,000 patients diagnosed and almost 12,000 deaths in 2022. Pa
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AZN
Sec Filings
- 6/25/24 - Form 6-K
- 6/25/24 - Form 6-K
- 6/18/24 - Form 6-K
- AZN's page on the SEC website