AstraZeneca's (AZN) Imfinzi Gets FDA Nod in Expanded Use [Yahoo! Finance]
AstraZeneca PLC - American Depositary Shares (AZN)
Last astrazeneca plc - american depositary shares earnings: 2/5 04:00 pm
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Source: Yahoo! Finance
for the treatment of adult patients with mismatch repair deficient (dMMR) advanced or recurrent endometrial cancer. The approval for expanded use of Imfinzi was based on data from a prespecified exploratory subgroup analysis by MMR status in the phase III DUO-E study. Data from the study showed that treatment with Imfinzi in combination with carboplatin and paclitaxel (chemotherapy), followed by Imfinzi monotherapy reduced the risk of disease progression or death by 58% in patients with dMMR endometrial cancer compared with chemotherapy alone. Treatment with Imfinzi and chemotherapy was generally well tolerated and manageable with no new safety concerns being observed. The three-arm DUO-E study is also evaluating Imfinzi plus chemotherapy followed by Imfinzi plus Lynparza as maintenance therapy in advanced or recurrent endometrial cancer. The Lynparza plus Imfinzi arm of the study has also met the primary endpoint of progression-free survival (PFS). The study continues to asse
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