Aerovate (AVTE) Down as Lead Drug Fails to Meet PAH Study Goals [Yahoo! Finance]
Aerovate Therapeutics, Inc. (AVTE)
Company Research
Source: Yahoo! Finance
from the mid-stage portion of the IIb/III IMPAHCT study evaluating its lead candidate, AV-101, in adults with pulmonary arterial hypertension (PAH). The mid to late-stage IMPAHCT study evaluated the efficacy, safety and tolerability of three different doses of AV-101 compared with placebo. Per the data readout from the phase IIb portion of the IMPAHCT study, AV-101, a novel dry powder inhaled formulation of imatinib, failed to meet the primary endpoint of change in pulmonary vascular resistance for any of the studied doses. Moreover, treatment with the candidate did not demonstrate any meaningful improvements in the study's secondary endpoint of change in the six-minute walk distance. The company has further reviewed data from several additional secondary endpoints of the phase IIb portion of the IMPAHCT study and found no meaningful improvements. Based on such poor outcomes, AVTE has decided, in agreement with the independent study advisory committee, to halt enrollment and s
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Earnings
- 8/12/24 - Miss
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Sec Filings
- 8/12/24 - Form 10-Q
- 8/2/24 - Form 4
- 7/8/24 - Form 8-K
- AVTE's page on the SEC website