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Stock impact report

Atossa Therapeutics updates protocol for breast cancer treatment trial [Yahoo! Finance]

Atossa Therapeutics, Inc. (ATOS) 
Last atossa therapeutics, inc. earnings: 11/13 04:10 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.atossagenetics.com
Company Research Source: Yahoo! Finance
in women with estrogen receptor positive (ER+) / human epidermal growth factor receptor 2 negative (HER2-) breast cancer. The study is assessing the combination regimen as a neoadjuvant treatment in newly diagnosed ER+/HER2- breast cancer patients. The protocol changes involve an increase in the dose of (Z)-endoxifen from 40mg to 80mg once daily, based on safety, efficacy, and pharmacokinetic data from the Phase II EVANGELINE study. The EVANGELINE study is targeting premenopausal women and has shown promising results with a significant reduction in the cellular proliferation marker Ki-67 and tumour size. Data from the initial 40mg cohort of the EVANGELINE study indicated a 92% average reduction in Ki-67 and a 37% average decrease in target lesion size after a 24-week treatment period. The trial has now progressed to an 80mg cohort, aiming to optimise drug concentrations for enhanced antitumor efficacy. In addition to the dose increase, the combination trial will now includ Show less Read more
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