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-0.0100000000000001 0 -0.0272727272727273 -0.0935064935064936 -0.0793506493506494 -0.164155844155844 -0.175844155844156 -0.145584415584416
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Athira Pharma's Alzheimer's Candidate Fails To Improve Cognition And Function In Patients With Mild/Moderate Disease, Stock Sinks [Yahoo! Finance]

Athira Pharma, Inc. (ATHA) 
Company Research Source: Yahoo! Finance
A -0.08 change in GST (the Global Statistical Test, a combination of results from measures of cognition (ADAS-Cog11) and function (ADCS-ADL23) favoring fosgonimeton that did not reach statistical significance (p=0.70) The change in cognition from baseline, for which a decrease from baseline represents an improvement, was -0.39 for the placebo group and -1.09 for the fosgonimeton-treated group, a difference of -0.70 (p=0.35) favoring fosgonimeton. In the fosgonimeton-treated group, function increased (improved) by 0.65 versus a decline of -0.02 in placebo, although this difference did not meet statistical significance (p=0.61). In addition, data across protein pathology, inflammation, and neurodegeneration biomarkers showed directional improvements with fosgonimeton treatment. “These are not the results we hoped for, as the lack of clinical decline in the placebo group, combined with the short duration of the study, may have impacted the trial's ability to translate the effect Show less Read more
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