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Stock impact report

TOLREMO Strengthens Scientific Advisory Board with Lung Cancer Expert Pasi A. Jänne [Yahoo! Finance]

ALX Oncology Holdings Inc. (ALXO) 
Company Research Source: Yahoo! Finance
Jänne, M.D., PhD, a world renowned translational thoracic medical oncologist, to its Scientific Advisory Board (SAB). Professor Jänne is one of the global leaders in the treatment of drug-resistant lung cancer and will be an important contributor to further TOLREMO's goal of preventing non-genetic cancer drug resistance. The company's lead candidate, TT125-802, is a novel small molecule CBP/p300 bromodomain inhibitor designed to block transcriptional resistance pathways that drive drug resistance to targeted cancer therapies. In an ongoing Phase I study, TT125-802 has shown encouraging signs of anti-tumor activity in advanced solid tumors, including partial responses in EGFR- and KRAS-mutated lung cancer, and a well-tolerated safety profile with no thrombocytopenia. TOLREMO's next step is to initiate clinical trials evaluating TT125-802 in combination with targeted therapies in EGFR- and KRAS-mutated lung cancer. "As one of the co-discoverers of EGFR mutations in lung cancer, Prof. Show less Read more
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