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Stock impact report

Aligos reports positive data from Phase IIa MASH treatment trial [Yahoo! Finance]

Aligos Therapeutics, Inc. - Common stock (ALGS) 
Company Research Source: Yahoo! Finance
clinical trial of ALG-055009, a thyroid hormone receptor beta agonist, for treating metabolic-dysfunction-associated steatohepatitis (MASH). The double-blind, randomised, placebo-controlled study enrolled 102 subjects with presumed MASH and stage I-III liver fibrosis. Subjects were assigned to receive one of four doses of ALG-055009 or placebo once a day for 12 weeks. The primary endpoint focused on the relative variation in liver fat content at week 12. Safety, pharmacokinetics (PK) and other non-invasive biomarkers/tests were also assessed in the trial. According to the findings, doses ranging from 0.5mg to 0.9mg of ALG-055009 led to notable median relative reductions in liver fat, with up to 70% of subjects experiencing a =30% relative decrease from baseline. The treatment also had a favourable tolerability profile, with no serious adverse events or signs of clinical hyper/hypothyroidism reported. Most of the treatment-emergent adverse events in the trial were observe Show less Read more
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