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Stock impact report

Adaptimmune leads in soft tissue sarcoma therapy with first TCR approval [Yahoo! Finance]

Adaptimmune Therapeutics plc - American Depositary Shares (ADAP) 
Last adaptimmune therapeutics plc - american depositary shares earnings: 5/9 07:30 am Check Earnings Report
Company Research Source: Yahoo! Finance
Tecelra becomes the first US-marketed TCR therapy for solid tumours. Patients of a specific HLA [human leukocyte antigen] type with tumours that express melanoma-associated antigen A4 and who have previously undergone chemotherapy are eligible for the therapy. The licence is based on the pivotal Phase II SPEARHEAD-1 study in which 43% of patients responded to the treatment and 4.5% achieved a complete response. The median duration of response was six months, yet 39% of patients maintained their response at one year or longer. Median overall survival (OS) for patients who responded was not reached, but the estimated 24-month OS for these patients is 70%. Currently, five-year survival rates for those diagnosed with the rare cancer are as low as 20% and no new options have reached the market in more than a decade. Cell therapies, specifically CAR-[chimeric antigen receptors]Ts, have revolutionised blood cancer treatment. These genetically engineered T cells are better equipped for re Show less Read more
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