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0 0 0.000146092037983849 0.000146092037983849 -0.00511322132943757 -0.0036523009495983 0.000730460189919634 -0.000730460189919634
Stock impact report

Mirum (MIRM) Soars on Interim Data From Liver Disease Studies [Yahoo! Finance]

Acrivon Therapeutics, Inc. (ACRV) 
Company Research Source: Yahoo! Finance
evaluated its oral ileal bile acid transporter inhibitor, volixibat, for treating patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). The phase IIb VISTAS study investigated volixibat for the treatment of PSC, while the phase IIb VANTAGE study evaluated volixibat for the treatment of PBC. Interim data from the VANTAGE study showed that treatment with volixibat led to a statistically significant improvement in pruritus and a placebo-adjusted difference of -2.32 points in the primary endpoint of pruritus, as measured by the Adult ItchRO scale. Meanwhile, 75% of the patients who were treated with volixibat achieved more than 50% reduction in serum bile acids. Also, treatment with volixibat resulted in significant improvement in fatigue versus placebo at week 16. Based on the above mentioned interim data, the VANTAGE study will continue to investigate volixibat 20 mg twice daily. Shares of Mirum have risen 11.7% so far this year against the Show less Read more
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