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OncoResponse reports data from Phase I solid tumour treatment trial [Yahoo! Finance]
Last regeneron pharmaceuticals, inc. earnings: 2/6 06:30 am
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US:NASDAQ Investor Relations: investor.regeneron.com
The multicentre, two-part, open-label, first-in-human study assessed OR502's safety, tolerability, and preliminary anti-tumour activity both as a standalone therapy and in conjunction with cemiplimab, an anti-programmed cell death protein (PD)-1, in patients with advanced solid tumours. The Part A dose-escalation phase of the trial was designed to identify the maximum-tolerated dose (MTD) or optimal dose for further evaluation. Part B, the expansion phase, treated subjects with advanced solid tumours at two separate doses of OR502 to establish the recommended Phase II dose (RP2D) and to evaluate preliminary anti-tumour activity. According to the findings, OR502 showed a safety profile, without any dose-limiting toxicity (DLT) or adverse events reported even at the maximum dose level. The treatment exhibited 'promising' early efficacy signals as a monotherapy, including two partial responses (PR) and nine cases of stable disease (SD) out of 17 subjects, with a 65% disease cont
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