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Stock impact report

ASCO 2024: Rakuten's photoimmunotherapy and Keytruda combo shows efficacy in HNSCC [Yahoo! Finance]

RAKUTEN GROUP INC S/ADR (RKUNY) 
NASDAQ:AMEX Investor Relations: global.rakuten.com/corp/investors
Company Research Source: Yahoo! Finance
Merck & Co (MSD)'s Keytruda (pembrolizumab) in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC). Following the positive results, the company now plans to start a global Phase III clinical trial evaluating the combination therapy of ASP-1929 and Keytruda as first-line therapy in recurrent HNSCC in the second half of this year. The study's primary endpoint will be overall survival. The results from the open-label Phase Ib/II study (NCT04305795) will be presented at the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago from 31 May to 4 June. ASP-1929 is an antibody-dye conjugate comprising of an epidermal growth factor receptor (EGFR) antagonist antibody, cetuximab, and a light-activated dye, IRDue 700DX. The therapy is activated locally by inducing a photochemical reaction when illuminated with red light using a laser device system. This potentially causes membrane damage in cancer cells, leading to selective nec Show less Read more
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