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0 0 0 0 0.00212572122684483 0.00212572122684483 0.00698451260249025 -0.0130580018220468
Stock impact report

Biohaven doses first subject in Phase I/II tumour treatment study [Yahoo! Finance]

Biohaven Ltd. Common Shares (BHVN) 
Last biohaven ltd. common shares earnings: 2/25 04:45 pm Check Earnings Report
US:NYSE Investor Relations: investors.biohavenpharma.com
Company Research Source: Yahoo! Finance
It is a first-in-human, multicentre, open-label trial structured into two segments: a Phase I dose escalation and a multicohort Phase II dose expansion. The initial phase will focus on determining the safety and tolerability of BHV-1510, establishing the recommended doses for expansion (RDEs), and identifying the maximum-tolerated dose (MTD), if applicable. The subsequent phase will evaluate the preliminary efficacy of the drug in signal-finding expansion cohorts. BHV-1510 features a homogeneous drug-antibody ratio (DAR) of four and employs a Trop-2-directed antibody linked to a Topoisomerase 1 (TopoIx) payload. The ADC employs a unique site-specific conjugation method and a highly stable and irreversible linker developed by GeneQuantum Healthcare. Preclinical studies have demonstrated that BHV-1510 delivers cellular cytotoxicity, bystander killing, and immunogenic cell death, potentially leading to enhanced monotherapy efficacy and synergistic effects along with anti-PD-1 Show less Read more
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